Multifaceted Networking of The Orphan Receptor Estrogen-Related Receptor Β in Breast Cancer Progression

Breast cancer death polls are rising at an alarming rate in females globally. It is a hormone-dependent disease that majorly regulated by estrogen. Several genetic and environmental factors the primary attributes of breast growth development. A higher proportion patients harbor estrogen receptor-positive (ER+ve) status. Estrogen related receptors orphan nuclear which include ERRα, ERRβ, ERRϒ exhibit sequence similarity with ERα. ERRα act as activators cancer. ERRβ expression downregulated cells patient samples, compared to healthy cells. The decreased primarily mediated proteasomal pathway protein level. restricts cell cycle progression cells, thereby impeding proliferation. Neddylation mediates its downregulation triggers oncogenic signalling Our study showed employing MLN4924, NAE inhibitor restore expressivity could provide successful cutting-edge therapeutic method. This review article illustrates regulatory role formation evolution cancer, making it effective candidate.